Alfentanil

Alfentanil is a potent, short-acting analgesic drug used for anesthesia in surgery. When alfentanil is administered to patients who were pre-treated with rifampin, an anti-tuberculosis drug, its level in our body (i.e. systemic exposure), was reduced 2- to 3-fold! A question arises: What are the rationales behind this interaction? Another ... Read More