Solubility Database (N-R)

This pharmaceutical solubility database contains the aqueous and chemical solubility of API and Excipients commonly used in pharmaceutical industry.

Nabumetone solubility – freely soluble in acetone; sparingly soluble in alcohol and in methanol; practically insoluble in water.

Nadolol solubility – freely soluble in alcohol and in methanol; soluble in water at pH 2; slightly soluble in chloroform, in methylene chloride, in isopropyl alcohol, and in water (between pH 7 and pH 10).

Nalidixic Acid solubility – soluble in chloroform, in methylene chloride, and in solutions of fixed alkali hydroxides and carbonates; slightly soluble in acetone, in alcohol, in methanol, and in toluene; very slightly soluble in ether and in water.

Naloxone Hydrochloride solubility – soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and in chloroform.

Naproxen solubility – soluble in chloroform, in dehydrated alcohol, and in alcohol; sparingly soluble in ether; practically insoluble in water.

Naproxen Sodium solubility – soluble in water and in methanol; sparingly soluble in alcohol; very slightly soluble in acetone; and practically insoluble in chloroform and in toluene.

Natamycin solubility – soluble in glacial acetic acid and in dimethylformamide; slightly soluble in methanol; practically insoluble in water.

Neomycin Sulfate solubility – freely soluble in water; very slightly soluble in alcohol; insoluble in acetone, in chloroform, and in ether.

Niacin solubility – freely soluble in boiling water, in boiling alcohol, and in solutions of alkali hydroxides and carbonates; sparingly soluble in water; practically insoluble in ether.

Niacinamide solubility – freely soluble in water and in alcohol; soluble in glycerin.

Nifedipine solubility – freely soluble in acetone; practically insoluble in water.

Nitrofurantoin solubility – soluble in dimethylformamide; very slightly soluble in water and in alcohol.

Nizatidine solubility – freely soluble in chloroform; soluble in methanol; sparingly soluble in water.

Norfloxacin solubility – freely soluble in acetic acid; sparingly soluble in chloroform; slightly soluble in acetone, in water, and in alcohol; very slightly soluble in methanol and in ethyl acetate; insoluble in ether.

Norgestrel solubility – freely soluble in chloroform; sparingly soluble in alcohol; insoluble in water.

Nystatin solubility – freely soluble in dimethylformamide and in dimethyl sulfoxide; very slightly soluble in methanol; practically insoluble or insoluble in water, in alcohol, in n-propyl alcohol, in n-butyl alcohol, in chloroform, and in ether.

Octyldodecanol solubility – soluble in alcohol and in ether; insoluble in water.

Ofloxacin solubility – sparingly soluble in chloroform; slightly soluble in alcohol, in methanol, and in water.

Olanzapine solubility – soluble in n-propanol; sparingly soluble in acetonitrile; slightly soluble in methanol and in dehydrated alcohol; practically insoluble in water.

Oleic Acid solubility – practically insoluble in water.

Olmesartan Medoxomil solubility – sparingly soluble in methanol; practically insoluble in water.

Olopatadine Hydrochloride solubility – very soluble in formic acid; sparingly soluble in water; very slightly soluble in dehydrated alcohol.

Omeprazole solubility – soluble in dichloromethane; sparingly soluble in methanol and in alcohol; very slightly soluble in water.

Omeprazole Magnesium solubility – sparingly soluble in methanol; slightly soluble in alcohol; very slightly soluble in water and in dichloromethane.

Ondansetron solubility – very soluble in acid solutions; sparingly soluble in water.

Orbifloxacin solubility – soluble in acetic acid; very slightly soluble in methanol, in water, and in chloroform; practically insoluble in ethanol and in diethyl ether.

Orlistat solubility – freely soluble in chloroform; very soluble in methanol and in alcohol; practically insoluble in water.

Oseltamivir Phosphate solubility – freely soluble in water; soluble in methanol, in dimethyl sulfoxide, and in propylene glycol; sparingly soluble in dimethylformamide; slightly soluble in alcohol; very slightly soluble in isopropyl alcohol.

Oxacillin Sodium solubility – freely soluble in water, in methanol, and in dimethyl sulfoxide; slightly soluble in absolute alcohol, in chloroform, in pyridine, and in methyl acetate; insoluble in ethyl acetate, in ether, in benzene, and in ethylene chloride.

Oxaliplatin solubility – slightly soluble in water; very slightly soluble in methanol; practically insoluble in alcohol.

Oxazepam solubility – slightly soluble in alcohol and in chloroform; very slightly soluble in ether; practically insoluble in water.

Oxcarbazepine solubility – soluble in acetic acid; sparingly soluble in chloroform; practically insoluble in water.

Oxfendazole solubility – slightly soluble in alcohol and in methylene chloride; practically insoluble in water.

Oxycodone Hydrochloride solubility – soluble in water; slightly soluble in alcohol.

Oxymetholone solubility – freely soluble in chloroform; soluble in dioxane; sparingly soluble in alcohol; slightly soluble in ether; practically insoluble in water.

Oxymorphone Hydrochloride solubility – freely soluble in water; sparingly soluble in alcohol and in ether.

Oxyquinoline Sulfate solubility – very soluble in water; freely soluble in methanol; slightly soluble in alcohol; practically insoluble in acetone and in ether.

Oxytetracycline solubility – freely soluble in 3 N hydrochloric acid and in alkaline solutions; sparingly soluble in alcohol; very slightly soluble in water.

Paclitaxel solubility – soluble in alcohol; insoluble in water.

Paliperidone solubility – sparingly soluble in 0.1 N hydrochloric acid and in methylene chloride; slightly soluble in N,N-dimethylformamide and in tetrahydrofuran; practically insoluble in water, in 0.1 N sodium hydroxide, and in hexane.

Palmitic Acid solubility – soluble in alcohol, in ether, and in chloroform; practically insoluble in water.

Palonosetron Hydrochloride solubility – freely soluble in water; soluble in propylene glycol; slightly soluble in ethanol; very slightly soluble to slightly soluble in isopropyl alcohol.

Pantoprazole Sodium solubility – freely soluble in water, in methanol, and in dehydrated alcohol; practically insoluble in hexane and in dichloromethane.

Paraffin solubility – freely soluble in chloroform, in ether, in volatile oils, and in most warm fixed oils; slightly soluble in dehydrated alcohol; insoluble in water and in alcohol.

Paricalcitol solubility – soluble in alcohol; insoluble in water.

Paroxetine Hydrochloride solubility – soluble in methanol and in alcohol; slightly soluble in water.

Penicillamine solubility – freely soluble in water; slightly soluble in alcohol; insoluble in chloroform and in ether.

Pentazocine solubility – freely soluble in chloroform; soluble in alcohol, in acetone, and in ether; sparingly soluble in benzene and in ethyl acetate; practically insoluble in water.

Pentobarbital solubility – very soluble in alcohol, in methanol, in ether, in chloroform, and in acetone; soluble in benzene; very slightly soluble in water and in carbon tetrachloride.

Pentobarbital Sodium solubility – very soluble in water; freely soluble in alcohol; practically insoluble in ether.

Phenobarbital solubility – soluble in alcohol, in ether, and in solutions of fixed alkali hydroxides and carbonates; sparingly soluble in chloroform; very slightly soluble in water.

Phenobarbital Sodium solubility – very soluble in water; soluble in alcohol; practically insoluble in ether and in chloroform.

Phenytoin solubility – soluble in hot alcohol; slightly soluble in cold alcohol, in chloroform, and in ether; practically insoluble in water.

Pilocarpine solubility – soluble in water, in alcohol, and in chloroform; sparingly soluble in ether and in benzene; practically insoluble in petroleum ether.

Pioglitazone Hydrochloride solubility – soluble in dimethylformamide; slightly soluble in dehydrated alcohol; very slightly soluble in acetone and in acetonitrile; practically insoluble in water; insoluble in ether.

Piperacillin solubility – very soluble in methanol; slightly soluble in isopropyl alcohol; very slightly soluble in ethyl acetate and practically insoluble to very slightly soluble in water.

Piperacillin Sodium solubility – freely soluble in water and in alcohol.

Piperazine solubility – soluble in water and in alcohol; insoluble in ether.

Piroxicam solubility – slightly soluble in alcohol and in aqueous alkaline solutions; very slightly soluble in water, in dilute acids, and in most organic solvents.

Polyvinyl Alcohol solubility – freely soluble in water at room temperature.

Potassium Benzoate solubility – freely soluble in water; soluble in 90% alcohol; sparingly soluble in alcohol.

Potassium Bicarbonate solubility – freely soluble in water; practically insoluble in alcohol.

Potassium Chloride solubility – freely soluble in water; insoluble in alcohol.

Potassium Citrate solubility – freely soluble in water; very slightly soluble in alcohol.

Potassium Hydroxide solubility – very soluble in boiling alcohol; freely soluble in water, in alcohol, and in glycerin.

Potassium Iodide solubility – very soluble in water and even more soluble in boiling water; freely soluble in glycerin; soluble in alcohol.

Povidone solubility – freely soluble in water, in methanol, and in alcohol; slightly soluble in acetone; practically insoluble in ether.

Povidone-Iodine solubility – soluble in water and in alcohol; practically insoluble in chloroform, in carbon tetrachloride, in ether, in solvent hexane, and in acetone.

Prazosin Hydrochloride solubility – slightly soluble in water, in methanol, in dimethylformamide, and in dimethylacetamide; very slightly soluble in alcohol; practically insoluble in chloroform and in acetone.

Prednisolone solubility – soluble in methanol and in dioxane; sparingly soluble in acetone and in alcohol; slightly soluble in chloroform; very slightly soluble in water.

Prednisolone Acetate solubility – slightly soluble in acetone, in alcohol, and in chloroform; practically insoluble in water.

Prednisone solubility – slightly soluble in alcohol, in chloroform, in dioxane, and in methanol; very slightly soluble in water.

Pregabalin solubility – freely soluble in water and in both basic and acidic aqueous solutions.

Prilocaine solubility – very soluble in alcohol and in acetone; slightly soluble in water.

Prilocaine Hydrochloride solubility – freely soluble in water and in alcohol; slightly soluble in chloroform; very slightly soluble in acetone; practically insoluble in ether.

Probenecid solubility – soluble in dilute alkali, in chloroform, in alcohol, and in acetone; practically insoluble in water and in dilute acids.

Progesterone solubility – soluble in alcohol, in acetone, and in dioxane; sparingly soluble in vegetable oils; practically insoluble in water.

Promethazine Hydrochloride solubility – freely soluble in water, in hot dehydrated alcohol, and in chloroform; practically insoluble in ether, in acetone, and in ethyl acetate.

Pyrazinamide solubility – sparingly soluble in water; slightly soluble in alcohol, in ether, and in chloroform.

Pyridoxine Hydrochloride solubility – freely soluble in water; slightly soluble in alcohol; insoluble in ether.

Pyrimethamine solubility – slightly soluble in acetone, in alcohol, and in chloroform; practically insoluble in water.

Quetiapine Fumarate solubility – soluble in 0.1 N hydrochloric acid; slightly soluble in water, in alcohol, and in methanol.

Quinidine Gluconate solubility – freely soluble in water; slightly soluble in alcohol.

Quinine Sulfate solubility – slightly soluble in water, in alcohol, and in chloroform; very slightly soluble in ether.

Ramipril solubility – freely soluble in methanol; sparingly soluble in water.

Reserpine solubility – freely soluble in acetic acid and in chloroform; slightly soluble in benzene; very slightly soluble in alcohol and in ether; insoluble in water.

Ribavirin solubility – freely soluble in water; slightly soluble in dehydrated alcohol.

Riboflavin solubility – soluble in dilute solutions of alkalies; very slightly soluble in water, in alcohol, and in isotonic sodium chloride solution; insoluble in ether and in chloroform.

Rifabutin solubility – soluble in chloroform and in methanol; sparingly soluble in alcohol; very slightly soluble in water.

Rifampin solubility – freely soluble in chloroform; soluble in ethyl acetate and in methanol; very slightly soluble in water.

Risedronate Sodium solubility – soluble in water and in aqueous solutions; insoluble in common organic solvents.

Risperidone solubility – soluble in methylene chloride; sparingly soluble in alcohol; practically insoluble in water.

Ritonavir solubility – freely soluble in methanol and in methylene chloride; very slightly soluble in acetonitrile; practically insoluble in water.

Rivastigmine Tartrate solubility – very soluble in water and in methanol; very slightly soluble in ethyl acetate.

Rizatriptan Benzoate solubility – soluble in water; sparingly soluble in alcohol; slightly soluble in methylene chloride.

Ropivacaine solubility – freely soluble in methylene chloride; soluble in ethanol; practically insoluble in water.

Rosiglitazone Maleate solubility – sparingly soluble in alcohol; slightly soluble in methylene chloride; practically insoluble to very slightly soluble in water.

Rosuvastatin Calcium solubility – soluble in dimethyl formamide, in dimethyl sulfoxide, in acetone, and in acetonitrile; sparingly soluble in methanol; sparingly soluble to slightly soluble in water; slightly soluble in ethanol.

Rotigotine solubility – soluble in anhydrous alcohol; very slightly soluble in heptane; practically insoluble in water.

Roxadustat solubility – Soluble in organic solvents, poorly soluble in water.

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