We know that solubility is the degree to which a substance dissolves in a solvent to make a solution. Where, water solubility or aqueous solubility refers to the ability of a substance (or solute) to dissolve in water.
This pharmaceutical solubility database contains the aqueous and chemical solubility of API and Excipients commonly used in pharmaceutical industry.
- Acetaminophen solubility – freely soluble in alcohol; soluble in boiling water and in 1 N sodium hydroxide; in water is much lower than ethanol.
- Acetazolamide solubility – sparingly soluble in practically boiling water; slightly soluble in alcohol; very slightly soluble in water.
- Acetylcysteine solubility – freely soluble in water and in alcohol; practically insoluble in chloroform and in ether.
- Acyclovir solubility – soluble in tetrahydrofuran; sparingly soluble in ethanol; practically insoluble in water.
- Adenosine solubility – slightly soluble in water; practically insoluble in alcohol.
- Adipic Acid solubility – freely soluble in alcohol and in methanol; soluble in boiling water and in acetone; slightly soluble in water.
- Albendazole solubility – freely soluble in anhydrous formic acid; very slightly soluble in ether and in methylene chloride; practically insoluble in alcohol and in water.
- Albuterol solubility – soluble in alcohol; sparingly soluble in water.
- Alfadex solubility – freely soluble in water and in propylene glycol; practically insoluble in ethanol and in methylene chloride.
- Alginic Acid solubility – soluble in alkaline solutions; insoluble in water and in organic solvents.
- Allopurinol solubility – soluble in solutions of potassium and sodium hydroxides; very slightly soluble in water and in alcohol; practically insoluble in chloroform and in ether.
- Alprazolam solubility – freely soluble in chloroform; soluble in alcohol; sparingly soluble in acetone; slightly soluble in ethyl acetate; insoluble in water.
- Aluminum Chloride solubility – very soluble in water; freely soluble in alcohol; soluble in glycerin.
- Aluminum Oxide solubility – it is very slightly soluble in dilute mineral acids and in solutions of alkali hydroxides.
- Amoxicillin solubility – slightly soluble in water and in methanol; insoluble in benzene, in carbon tetrachloride, and in chloroform.
- Amphotericin B solubility – soluble in dimethylformamide, in dimethyl sulfoxide, and in propylene glycol; slightly soluble in methanol; insoluble in water, in anhydrous alcohol, in ether, in benzene, and in toluene.
- Ampicillin solubility – slightly soluble in water and in methanol; insoluble in benzene, in carbon tetrachloride, and in chloroform.
- Ampicillin Sodium solubility – very soluble in water and in isotonic sodium chloride and dextrose solutions.
- Antazoline Phosphate solubility – soluble in water; sparingly soluble in methanol; practically insoluble in benzene and in ether.
- Arginine solubility – freely soluble in water; sparingly soluble in alcohol; insoluble in ether.
- Aripiprazole solubility – freely soluble in dichloromethane; sparingly soluble in toluene; insoluble in methanol and in water.
- Ascorbic Acid solubility – freely soluble in water; sparingly soluble in alcohol; insoluble in chloroform, in ether, and in benzene.
- Aspartame solubility – sparingly soluble in water; slightly soluble in alcohol.
- Aspirin solubility – freely soluble in alcohol; soluble in chloroform and in ether; sparingly soluble in absolute ether; slightly soluble in water.
- Atenolol solubility – freely soluble in methanol; sparingly soluble in alcohol; slightly soluble in water and in isopropanol.
- Atorvastatin Calcium solubility – soluble to freely soluble in methanol; slightly soluble in alcohol; insoluble to very slightly soluble in distilled water, in pH 7.4 phosphate buffer, and in acetonitrile; insoluble in aqueous solutions of pH 4 and below.
- Atropine solubility – Freely soluble in alcohol and in chloroform; soluble in glycerin and in ether; slightly soluble in water; sparingly soluble in water at 80°.
- Azatadine Maleate solubility – freely soluble in water, in alcohol, in chloroform, and in methanol; practically insoluble in benzene and in ether.
- Azithromycin solubility – freely soluble in anhydrous ethanol and in methylene chloride; practically insoluble in water.
- Bacitracin solubility – freely soluble in water; soluble in alcohol, in methanol, and in glacial acetic acid, the solution in the organic solvents usually showing some insoluble residue; insoluble in acetone, in chloroform, and in ether.
- Baclofen solubility – slightly soluble in water; very slightly soluble in methanol; insoluble in chloroform.
- Barium Sulfate solubility – practically insoluble in water, in organic solvents, and in solutions of acids and of alkalies.
- Beclomethasone Dipropionate solubility – very soluble in chloroform; freely soluble in acetone and in alcohol; very slightly soluble in water.
- Bentonite solubility – insoluble in water, but swells to approximately twelve times its volume when added to water; insoluble in, and does not swell in, organic solvents.
- Benzalkonium Chloride solubility – very soluble in water and in alcohol. Anhydrous form freely soluble in benzene, and slightly soluble in ether.
- Benzoic Acid solubility – freely soluble in alcohol, in chloroform, and in ether; slightly soluble in water.
- Benzyl Alcohol solubility – freely soluble in 50% alcohol; sparingly soluble in water. Miscible with alcohol, with ether, and with chloroform.
- Benzyl Benzoate solubility – practically insoluble in water and in glycerin. Miscible with alcohol, with ether, and with chloroform.
- Beta Carotene solubility – soluble in carbon disulfide, in benzene, and in chloroform; sparingly soluble in ether, in solvent hexane, and in vegetable oils; practically insoluble in methanol and in alcohol; insoluble in water, in acids, and in alkalies.
- Betadex solubility – sparingly soluble in water.
- Betamethasone solubility – sparingly soluble in acetone, in alcohol, in dioxane, and in methanol; very slightly soluble in chloroform and in ether; insoluble in water.
- Betaxolol Hydrochloride solubility – freely soluble in water, in alcohol, in chloroform, and in methanol.
- Biotin solubility – very slightly soluble in water and in alcohol; insoluble in other common organic solvents.
- Bisacodyl solubility – soluble in chloroform and in benzene; sparingly soluble in alcohol and in methanol; slightly soluble in ether; practically insoluble in water.
- Bismuth Subsalicylate solubility – practically insoluble in water, in alcohol, and in ether. Reacts with alkalies and mineral acids.
- Bisoprolol Fumarate solubility – very soluble in water and in methanol; freely soluble in chloroform, in glacial acetic acid, and in alcohol; slightly soluble in acetone and in ethyl acetate.
- Bleomycin Sulfate solubility – very soluble in water.
- Boric Acid solubility – freely soluble in glycerin, in boiling water, and in boiling alcohol; soluble in water and in alcohol.
- Brimonidine Tartrate solubility – soluble in water; practically insoluble in anhydrous ethanol and in toluene.
- Brinzolamide solubility – slightly soluble in alcohol and in methanol; insoluble in water.
- Brompheniramine Maleate solubility – freely soluble in water; soluble in alcohol and in chloroform; slightly soluble in ether and in benzene.
- Budesonide solubility – freely soluble in chloroform; sparingly soluble in alcohol; practically insoluble in water and in heptane.
- Bupropion Hydrochloride solubility – soluble in water, in 0.1 N hydrochloric acid, and in alcohol.
- Buspirone Hydrochloride solubility – very soluble in water; freely soluble in methanol and in methylene chloride; sparingly soluble in ethanol and in acetonitrile; very slightly soluble in ethyl acetate; practically insoluble in hexanes.
- Butabarbital solubility – soluble in alcohol, in chloroform, in ether, and in solutions of alkali hydroxides and carbonates; very slightly soluble in water.
- Butoconazole Nitrate solubility – sparingly soluble in methanol; slightly soluble in acetonitrile, in acetone, in dichloromethane, and in tetrahydrofuran; very slightly soluble in ethyl acetate; practically insoluble in water.
- Butyl Alcohol solubility – soluble in water. Miscible with alcohol, with ether, and with many other organic solvents.
- Butylene Glycol solubility – It is miscible with water, with acetone, and with ether in all proportions; immiscible with fixed oils.
- Butyl Palmitostearate solubility – soluble in acetone, in alcohol, in ether, in mineral oils, and in vegetable oils; practically insoluble in water and in propylene glycol.
- Butyl Stearate solubility – soluble in acetone, in alcohol, in ether, in mineral oils, and in vegetable oils; practically insoluble in water and in propylene glycol.
- Butylated Hydroxyanisole solubility – freely soluble in alcohol, in propylene glycol, in chloroform, and in ether; insoluble in water.
- Butylated Hydroxytoluene solubility – freely soluble in alcohol, in chloroform, and in ether; insoluble in water and in propylene glycol.
- Butylparaben solubility – freely soluble in acetone, in alcohol, in ether, and in propylene glycol; very slightly soluble in water and in glycerin.
- Cabergoline solubility – freely soluble in alcohol (96%); slightly soluble in 0.1 M hydrochloric acid; very slightly soluble in hexane; practically insoluble in water.
- Caffeine solubility – freely soluble in chloroform; sparingly soluble in water and in alcohol; slightly soluble in ether.
- Calcitriol solubility – freely soluble in alcohol; soluble in ether and in fatty oils; practically insoluble in water.
- Calcium Acetate solubility – freely soluble in water; slightly soluble in methanol; practically insoluble in acetone, in dehydrated alcohol, and in benzene.
- Calcium Carbonate solubility – practically insoluble in water. Its solubility in water is increased by the presence of any ammonium salt or of carbon dioxide.
- Calcium Chloride solubility – very soluble in boiling water; freely soluble in water, in alcohol, and in boiling alcohol.
- Calcium Citrate solubility – freely soluble in diluted 3 N hydrochloric acid and in diluted 2 N nitric acid; slightly soluble in water; insoluble in alcohol.
- Calcium Hydroxide solubility – soluble in glycerin and in syrup; slightly soluble in water; very slightly soluble in boiling water; insoluble in alcohol.
- Dibasic Calcium Phosphate solubility – soluble in 3 N hydrochloric acid and in 2 N nitric acid; practically insoluble in water; insoluble in alcohol.
- Tribasic Calcium Phosphate solubility – freely soluble in 3 N hydrochloric acid and in 2 N nitric acid; practically insoluble in water; insoluble in alcohol.
- Calcium Silicate solubility – insoluble in water.
- Calcium Stearate solubility – insoluble in water, in alcohol, and in ether.
- Camphor solubility – slightly soluble in water; very soluble in alcohol, in chloroform, and in ether; freely soluble in carbon disulfide, in solvent hexane, and in fixed and volatile oils.
- Capecitabine solubility – freely soluble in methanol; soluble in acetonitrile and in alcohol; sparingly soluble in water.
- Capsaicin solubility – soluble in alcohol, in benzene, in chloroform; slightly soluble in carbon disulfide; practically insoluble in cold water.
- Carbamazepine solubility – soluble to very slightly soluble in alcohol and in acetone; practically insoluble in water.
- Carbidopa solubility – freely soluble in 3 N hydrochloric acid; slightly soluble in water, and in methanol; practically insoluble in alcohol, in acetone, in chloroform, and in ether.
- Carbomer 910 solubility – when neutralized with alkali hydroxides or with amines, it dissolves in water, in alcohol, and in glycerin.
- Carboxymethylcellulose Sodium solubility – easily dispersed in water to form colloidal solutions. Insoluble in alcohol, in ether, and in most other organic solvents.
- Carisoprodol solubility – freely soluble in alcohol, in chloroform, and in acetone; very slightly soluble in water.
- Carmellose solubility – practically insoluble in ethanol (99.5%). Swells with water to form a suspension.
- Carvedilol solubility – slightly soluble in alcohol; practically insoluble in water and in dilute acids.
- Castor Oil solubility – soluble in alcohol. Miscible with dehydrated alcohol, with glacial acetic acid, with chloroform, and with ether.
- Cefaclor solubility – slightly soluble in water; practically insoluble in methanol, in chloroform, and in benzene.
- Cefadroxil solubility – slightly soluble in water; practically insoluble in alcohol, in chloroform, and in ether.
- Cefazolin solubility – soluble in dimethylformamide and in pyridine; sparingly soluble in acetone; slightly soluble in alcohol, in methanol, and in water; very slightly soluble in ethyl acetate, in isopropyl alcohol, and in methyl isobutyl ketone; practically insoluble in benzene, in chloroform, in ether, and in methylene chloride.
- Cefepime Hydrochloride solubility – freely soluble in water.
- Cefixime solubility – soluble in methanol and in propylene glycol; slightly soluble in alcohol, in acetone, and in glycerin; very slightly soluble in 70% sorbitol and in octanol; practically insoluble in ether, in ethyl acetate, in hexane, and in water.
- Cefotaxime Sodium solubility – freely soluble in water; practically insoluble in organic solvents.
- Cefpodoxime Proxetil solubility – freely soluble in dehydrated alcohol; soluble in acetonitrile and in methanol; slightly soluble in ether; very slightly soluble in water.
- Ceftizoxime Sodium solubility – freely soluble in water.
- Cefuroxime Axetil solubility – amorphous form is freely soluble in acetone; soluble in chloroform, in ethyl acetate, and in methanol; slightly soluble in dehydrated alcohol; insoluble in ether and in water. The crystalline form is freely soluble in acetone; sparingly soluble in chloroform, in ethyl acetate, and in methanol; slightly soluble in dehydrated alcohol; insoluble in ether and in water.
- Cefuroxime Sodium solubility – freely soluble in water; soluble in methanol; very slightly soluble in alcohol, in ether, in ethyl acetate, and in chloroform.
- Celecoxib solubility – soluble to freely soluble in ethanol; soluble in methylene chloride; practically insoluble in water.
- Cellulose Acetate solubility – high acetyl content cellulose acetates generally have more limited solubility in commonly used organic solvents than low acetyl content cellulose acetates, but are more soluble in methylene chloride.
- Microcrystalline Cellulose solubility – practically insoluble in sodium hydroxide solution (1 in 20); insoluble in water, in dilute acids, and in most organic solvents.
- Silicified Microcrystalline Cellulose solubility – slightly soluble in sodium hydroxide solution (1 in 20); practically insoluble in water, in acetone, in ethanol, in toluene, and in diluted acid.
- Microcrystalline Cellulose and Carboxymethylcellulose Sodium solubility – swells in water, producing, when dispersed, a white, opaque dispersion or gel. Insoluble in organic solvents and in dilute acids.
- Cephalexin solubility – slightly soluble in water; practically insoluble in alcohol, in chloroform, and in ether.
- Cephalexin Hydrochloride solubility – soluble to the extent of 10 mg per mL in water, in acetone, in acetonitrile, in alcohol, in dimethylformamide, and in methanol; practically insoluble in chloroform, in ether, in ethyl acetate, and in isopropyl alcohol.
- Cephalothin Sodium solubility – freely soluble in water, in saline TS, and in dextrose solutions; insoluble in most organic solvents.
- Cephradine solubility – sparingly soluble in water; very slightly soluble in alcohol and in chloroform; practically insoluble in ether.
- Cetirizine Hydrochloride solubility – freely soluble in water; practically insoluble in acetone and in methylene chloride.
- Cetostearyl Alcohol solubility – soluble in alcohol and in ether; insoluble in water.
- Cetyl Alcohol solubility – soluble in alcohol and in ether, the solubility increasing with an increase in temperature; insoluble in water.
- Cetyl Palmitate solubility – freely soluble in alcohol and in ether; practically insoluble in water.
- Chlorambucil solubility – freely soluble in acetone; soluble in dilute alkali; very slightly soluble in water.
- Chloramphenicol solubility – freely soluble in alcohol, in propylene glycol, in acetone, and in ethyl acetate; slightly soluble in water.
- Chlordiazepoxide solubility – sparingly soluble in chloroform and in alcohol; insoluble in water.
- Chlorhexidine Acetate solubility – soluble in alcohol; sparingly soluble in water; slightly soluble in glycerol and in propylene glycol.
- Chlorobutanol solubility – freely soluble in alcohol, in ether, in chloroform, and in volatile oils; soluble in glycerin; slightly soluble in water.
- Chlorocresol solubility – very soluble in alcohol; soluble in ether, in terpenes, in fixed oils, and in solutions of alkali hydroxides; slightly soluble in water and more soluble in hot water.
- Chloroquine solubility – soluble in dilute acids, in chloroform, and in ether; very slightly soluble in water.
- Chlorthalidone solubility – soluble in methanol; slightly soluble in alcohol; practically insoluble in water, in ether, and in chloroform.
- Cholecalciferol solubility – soluble in alcohol, in chloroform, and in fatty oils; insoluble in water.
- Choline Chloride solubility – Soluble in alcohol and in water.
- Ciclopirox solubility – freely soluble in ethanol and in methylene chloride; soluble in ether; slightly soluble in water.
- Cimetidine solubility – freely soluble in methanol; soluble in alcohol and in polyethylene glycol 400; sparingly soluble in isopropyl alcohol; slightly soluble in water and in chloroform; practically insoluble in ether.
- Ciprofloxacin Hydrochloride solubility – sparingly soluble in water; slightly soluble in acetic acid and in methanol; very slightly soluble in dehydrated alcohol; practically insoluble in acetone, in acetonitrile, in ethyl acetate, in hexane, and in methylene chloride.
- Citalopram Hydrobromide solubility – soluble in alcohol; sparingly soluble in water and in dehydrated alcohol.
- Anhydrous Citric Acid solubility – very soluble in water; freely soluble in alcohol; very slightly soluble in ether.
- Citric Acid Monohydrate solubility – very soluble in water; freely soluble in alcohol; very slightly soluble in ether.
- Clarithromycin solubility – soluble in acetone; slightly soluble in dehydrated alcohol, in methanol, and in acetonitrile, and in phosphate buffer at pH values of 2 to 5; practically insoluble in water.
- Clavulanate Potassium solubility – freely soluble in water, but stability in aqueous solution is not good, optimum stability at a pH of 6.0 to 6.3; soluble in methanol, with decomposition.
- Clindamycin Hydrochloride solubility – freely soluble in water, in dimethylformamide, and in methanol; soluble in alcohol; practically insoluble in acetone.
- Clobetasol Propionate solubility – soluble in acetone, in dimethyl sulfoxide, in chloroform, in methanol, and in dioxane; sparingly soluble in ethanol; slightly soluble in benzene and in diethyl ether; practically insoluble in water.
- Clonazepam solubility – sparingly soluble in acetone and in chloroform; slightly soluble in alcohol and in ether; insoluble in water.
- Clonidine solubility – freely soluble in methanol and in alcohol.
- Clotrimazole solubility – freely soluble in methanol, in chloroform, and in alcohol; freely soluble to soluble in acetone; practically insoluble in water.
- Cloxacillin Sodium solubility – freely soluble in water; soluble in alcohol; slightly soluble in chloroform.
- Clozapine solubility – soluble in chloroform, in acetone, and in alcohol; sparingly soluble in acetonitrile; insoluble in water.
- Copovidone solubility – freely soluble in water, in alcohol, and in methylene chloride; practically insoluble in ether.
- Cresol solubility – sparingly soluble in water.
- Croscarmellose Sodium solubility – partially soluble in water; insoluble in alcohol, in ether, and in other organic solvents.
- Crospovidone solubility – insoluble in water and in ordinary organic solvents.
- Cyanocobalamin solubility – soluble in alcohol; sparingly soluble in water; insoluble in acetone, in chloroform, and in ether.
- Cyclophosphamide solubility – Soluble in water and in alcohol.
- Cyclosporine solubility – practically insoluble in water.
- Cytarabine solubility – freely soluble in water; slightly soluble in alcohol and in chloroform.
- Dantrolene Sodium solubility – sparingly soluble in dimethylformamide and in glycerine; sparingly soluble to practically insoluble in acetone.
- Dapagliflozin Propanediol solubility – freely soluble in methanol, in tetrahydrofuran, in ethanol, and in acetone; soluble in acetonitrile; slightly soluble in water.
- Daprodustat solubility – soluble in organic solvents.
- Dapsone solubility – soluble in acetone and in dilute mineral acids; sparingly soluble in alcohol; very slightly soluble in water.
- Denatonium Benzoate solubility – freely soluble in water and in alcohol.
- Dexamethasone solubility – sparingly soluble in acetone, in alcohol, in dioxane, and in methanol; slightly soluble in chloroform; very slightly soluble in ether; practically insoluble in water.
- Dextran solubility – very soluble in water; sparingly soluble in alcohol.
- Dextrin solubility – usually very soluble in water.
- Dextromethorphan solubility – freely soluble in chloroform; practically insoluble in water.
- Dextrose solubility – very soluble in boiling water; freely soluble in water.
- Diatrizoate Meglumine solubility – freely soluble in water.
- Diazepam solubility – freely soluble in chloroform; soluble in alcohol; practically insoluble in water.
- Diazoxide solubility – sparingly soluble to practically insoluble in water.
- Diclofenac Potassium solubility – freely soluble in methanol; soluble in alcohol; sparingly soluble in water; slightly soluble in acetone.
- Diclofenac Sodium solubility – freely soluble in methanol; soluble in ethanol; sparingly soluble in water; practically insoluble in chloroform and in ether.
- Digitoxin solubility – sparingly soluble in chloroform; slightly soluble in alcohol; very slightly soluble in ether; practically insoluble in water.
- Digoxin solubility – freely soluble in pyridine; slightly soluble in diluted alcohol and in chloroform; practically insoluble in water and in ether.
- Dinoprost Tromethamine solubility – very soluble in water; freely soluble in dimethylformamide; soluble in methanol; slightly soluble in chloroform.
- Docetaxel solubility – freely soluble in acetone; soluble in methanol; practically insoluble in water.
- Docusate Sodium solubility – very soluble in solvent hexane; freely soluble in alcohol and in glycerin; sparingly soluble in water.
- Doxorubicin Hydrochloride solubility – soluble in water, in isotonic sodium chloride solution, and in methanol; practically insoluble in chloroform, in ether, and in other organic solvents.
- Doxycycline solubility – freely soluble in dilute acid and in alkali hydroxide solutions; very slightly soluble in alcohol and in water; practically insoluble in chloroform and in ether.
- Doxylamine Succinate solubility – very soluble in water; freely soluble in chloroform and in alcohol; very slightly soluble in ether.
- Drospirenone solubility – freely soluble in methylene chloride; soluble in acetone and in methanol; sparingly soluble in ethyl acetate and in alcohol; practically insoluble in hexane and in water.
- Duloxetine Hydrochloride solubility – freely soluble in methanol; sparingly soluble in water; practically insoluble in hexane.
- Dutasteride solubility – soluble in ethanol and methanol; slightly soluble in polyethylene glycol 400; and insoluble in water.
- Dydrogesterone solubility – sparingly soluble in alcohol; practically insoluble in water.
- Edetate Disodium solubility – Soluble in water.
- Enrofloxacin solubility – Very slightly soluble in water at pH 7.
- Entacapone solubility – practically insoluble in water.
- Entecavir solubility – practically insoluble to slightly soluble in water.
- Ergocalciferol solubility – soluble in alcohol, in chloroform, in ether, and in fatty oils; insoluble in water.
- Erythromycin solubility – slightly soluble in water.
- Erythromycin Stearate solubility – practically insoluble in water.
- Escitalopram Oxalate solubility – sparingly soluble in water and in alcohol.
- Esomeprazole Magnesium solubility – slightly soluble in water.
- Estazolam solubility – sparingly soluble in ethanol; practically insoluble in water and in ether.
- Estradiol solubility – practically insoluble in water.
- Estriol solubility – sparingly soluble in alcohol; insoluble in water.
- Ethyl Oleate solubility – insoluble in water.
- Ethyl Vanillin solubility – sparingly soluble in water at 50°C.
- Ethylcellulose solubility – insoluble in water.
- Ethylparaben solubility – slightly soluble in water and in glycerin.
- Ethylparaben Sodium solubility – freely soluble in water.
- Etoposide solubility – very slightly soluble in water.
- Etoposide Phosphate solubility – freely soluble in water.
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