Solubility Database (S-Z)

This pharmaceutical solubility database contains the aqueous and chemical solubility of API and Excipients commonly used in pharmaceutical industry.

  • Saccharin solubility – soluble in boiling water; sparingly soluble in alcohol; slightly soluble in water, in chloroform, and in ether.

  • Saccharin Sodium solubility – freely soluble in water; sparingly soluble in alcohol.

  • Safflower Oil solubility – insoluble in water.

  • Salicylic Acid solubility – freely soluble in alcohol and in ether; soluble in boiling water; sparingly soluble in chloroform; slightly soluble in water and in benzene.

  • Salmeterol Xinafoate solubility – soluble in methanol; slightly soluble in alcohol, in isopropanol, and in chloroform; practically insoluble in water (pH 8), and in saline solution (0.9% w/w).

  • Secobarbital solubility – freely soluble in alcohol, in ether, and in solutions of fixed alkali hydroxides and carbonates; soluble in chloroform; very slightly soluble in water.

  • Secobarbital Sodium solubility – very soluble in water; soluble in alcohol; practically insoluble in ether.

  • Sertraline Hydrochloride solubility – sparingly soluble or slightly soluble in absolute alcohol; slightly soluble in water and in isopropanol; and slightly or very slightly soluble in acetone.

  • Sildenafil Citrate solubility – Slightly soluble in water and in methanol; practically insoluble in hexane.

  • Silicon Dioxide solubility – soluble in hot solutions of alkali hydroxides; insoluble in water, in alcohol, and in other organic solvents.

  • Silver Nitrate solubility – very soluble in water and even more so in boiling water; freely soluble in boiling alcohol; sparingly soluble in alcohol; slightly soluble in ether.

  • Simethicone solubility – liquid phase is soluble in chloroform, in ether, and in benzene, but silicon dioxide remains as a residue in these solvents. Insoluble in water and in alcohol.

  • Simvastatin solubility – freely soluble in chloroform, in methanol, and in alcohol; sparingly soluble in propylene glycol; very slightly soluble in hexane; practically insoluble in water.

  • Sitagliptin Phosphate solubility – soluble in water; very slightly soluble in anhydrous ethanol; practically insoluble in heptane.

  • Sodium Acetate solubility – very soluble in water; soluble in alcohol.

  • Sodium Alginate solubility – soluble in water, forming a viscous, colloidal solution; insoluble in alcohol.

  • Sodium Ascorbate solubility – freely soluble in water; very slightly soluble in alcohol; insoluble in chloroform and in ether.

  • Sodium Benzoate solubility – freely soluble in water; soluble in 90% alcohol; sparingly soluble in alcohol.

  • Sodium Bicarbonate solubility – soluble in water; insoluble in alcohol.

  • Sodium Bisulfite solubility – freely soluble in cold water and in hot water; sparingly soluble in alcohol.

  • Sodium Carbonate solubility – very soluble in boiling water; freely soluble in water.

  • Sodium Chloride solubility – freely soluble in water; soluble in glycerin; slightly soluble in alcohol.

  • Sodium Citrate solubility – freely soluble in water; insoluble in alcohol.

  • Sodium Fluoride solubility – soluble in water; insoluble in alcohol.

  • Sodium Hydroxide solubility – freely soluble in water and in alcohol.

  • Sodium Iodide solubility – very soluble in water; freely soluble in alcohol and in glycerin.

  • Sodium Lauryl Sulfate solubility – freely soluble in water, forming an opalescent solution.

  • Sodium Metabisulfite solubility – freely soluble in water and in glycerin; slightly soluble in alcohol.

  • Sodium Nitrite solubility – freely soluble in water; sparingly soluble in alcohol.

  • Sodium Nitroprusside solubility – freely soluble in water; insoluble in alcohol.

  • Sodium Phosphate (Dibasic) solubility – freely soluble in water; practically insoluble in alcohol.

  • Sodium Phosphate (Tribasic) solubility – freely soluble in water; insoluble in alcohol.

  • Sodium Picosulfate solubility – freely soluble in water; slightly soluble in alcohol.

  • Sodium Polystyrene Sulfonate solubility – insoluble in water.

  • Sodium Propionate solubility – very soluble in water; soluble in alcohol.

  • Sodium Salicylate solubility – very soluble in boiling water and in boiling alcohol; freely (and slowly) soluble in water and in glycerin; slowly soluble in alcohol.

  • Sodium Starch Glycolate solubility – practically insoluble in water.

  • Sodium Stearate solubility – slowly soluble in cold water and in cold alcohol; readily soluble in hot water and in hot alcohol.

  • Sodium Stearyl Fumarate solubility – slightly soluble in methanol; practically insoluble in water.

  • Sodium Succinate solubility – freely soluble in water.

  • Sodium Thiosulfate solubility – very soluble in water; insoluble in alcohol.

  • Solifenacin Succinate solubility – freely soluble in water and in methanol.

  • Sorafenib Tosylate solubility – soluble in PEG 400; slightly soluble in ethanol; practically insoluble in aqueous media and in heptane.

  • Sorbic Acid solubility – soluble in alcohol and in ether; slightly soluble in water.

  • Sorbitan Monostearate solubility – soluble, with haze, above 50° in mineral oil and in ethyl acetate; insoluble in cold water and in acetone.

  • Sorbitol solubility – very soluble in water; sparingly soluble in alcohol; and practically insoluble in ethyl ether. Is hygroscopic.

  • Spectinomycin Hydrochloride solubility – freely soluble in water; practically insoluble in alcohol, in chloroform, and in ether.

  • Spironolactone solubility – freely soluble in benzene and in chloroform; soluble in ethyl acetate and in alcohol; slightly soluble in methanol and in fixed oils; practically insoluble in water.

  • Starch (Corn) solubility – insoluble in cold water and in alcohol.

  • Starch (Pregelatinized) solubility – slightly soluble to soluble in cold water; insoluble in alcohol.

  • Stearic Acid solubility – freely soluble in chloroform and in ether; soluble in alcohol; practically insoluble in water.

  • Stearyl Alcohol solubility – soluble in alcohol and in ether; insoluble in water.

  • Streptomycin Sulfate solubility – freely soluble in water; very slightly soluble in alcohol; practically insoluble in chloroform.

  • Sucralfate solubility – practically insoluble in water, in alcohol, and in methylene chloride.

  • Sucralose solubility – freely soluble in water, in methanol, and in alcohol; slightly soluble in ethyl acetate.

  • Sucrose solubility – very soluble in water; slightly soluble in alcohol; practically insoluble in dehydrated alcohol.

  • Sulfabenzamide solubility – soluble in alcohol, in acetone, and in sodium hydroxide TS; insoluble in water and in ether.

  • Sulfacetamide solubility – freely soluble in dilute mineral acids and in solutions of potassium and sodium hydroxides; soluble in alcohol; slightly soluble in water and in ether; very slightly soluble in chloroform; practically insoluble in benzene.

  • Sulfadiazine solubility – freely soluble in dilute mineral acids, in solutions of potassium and sodium hydroxides, and in ammonia TS; sparingly soluble in alcohol and in acetone; slightly soluble in human serum at 37°; practically insoluble in water.

  • Sulfamethazine solubility – soluble in acetone; slightly soluble in alcohol; very slightly soluble in water and in ether.

  • Sulfamethizole solubility – freely soluble in solutions of ammonium, potassium, and sodium hydroxides; soluble in dilute mineral acids and in acetone; sparingly soluble in alcohol; very slightly soluble in water, in chloroform, and in ether; practically insoluble in benzene.

  • Sulfamethoxazole solubility – freely soluble in acetone and in dilute solutions of sodium hydroxide; sparingly soluble in alcohol; practically insoluble in water, in ether, and in chloroform.

  • Sulfapyridine solubility – freely soluble in dilute mineral acids and in solutions of potassium and sodium hydroxides; sparingly soluble in acetone; slightly soluble in alcohol; very slightly soluble in water.

  • Sulfasalazine solubility – soluble in aqueous solutions of alkali hydroxides; very slightly soluble in alcohol; practically insoluble in water, in ether, in chloroform, and in benzene.

  • Sulfathiazole solubility – soluble in acetone, in dilute mineral acids, in solutions of alkali hydroxides, and in 6 N ammonium hydroxide; slightly soluble in alcohol; very slightly soluble in water.

  • Sulfuric Acid solubility – miscible with water and with alcohol with the generation of much heat.

  • Sumatriptan solubility – very slightly soluble in water.

  • Sumatriptan Succinate solubility – freely soluble in water; sparingly soluble in methanol; practically insoluble in methylene chloride.

  • Suprofen solubility – sparingly soluble in water.

  • Tacrolimus solubility – very soluble in methanol; freely soluble in N,N-dimethylformamide, and in alcohol; practically insoluble in water.

  • Tadalafil solubility – freely soluble in dimethyl sulfoxide; slightly soluble in methylene chloride; practically insoluble in water.

  • Talc solubility – practically insoluble in water.

  • Tamoxifen Citrate solubility – soluble in methanol; very slightly soluble in water, in acetone, in chloroform, and in alcohol.

  • Tamsulosin Hydrochloride solubility – freely soluble in formic acid; sparingly soluble in methanol; slightly soluble in water and in dehydrated alcohol; practically insoluble in ether.

  • Tartaric Acid solubility – very soluble in water; freely soluble in alcohol.

  • Telmisartan solubility – sparingly soluble in methylene chloride; slightly soluble in methanol; practically insoluble in water.

  • Terbinafine Hydrochloride solubility – freely soluble in dehydrated alcohol and in methanol; slightly soluble in acetone; very slightly or slightly soluble in water.

  • Terconazole solubility – freely soluble in methylene chloride; soluble in acetone; sparingly soluble in alcohol; practically insoluble in water.

  • Tetracycline solubility – freely soluble in dilute acid and in alkali hydroxide solutions; sparingly soluble in alcohol; very slightly soluble in water; practically insoluble in chloroform and in ether.

  • Tetracycline Hydrochloride solubility – soluble in water and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol; practically insoluble in chloroform and in ether.

  • Theophylline solubility – freely soluble in solutions of alkali hydroxides and in ammonia; sparingly soluble in alcohol, in chloroform, and in ether; slightly soluble in water, but more soluble in hot water.

  • Thiamine Hydrochloride solubility – freely soluble in water; soluble in glycerin; slightly soluble in alcohol; insoluble in ether and in benzene.

  • Thiamine Mononitrate solubility – sparingly soluble in water; slightly soluble in alcohol; very slightly soluble in chloroform.

  • Thimerosal solubility – freely soluble in water; soluble in alcohol; practically insoluble in ether.

  • Thiopental Sodium solubility – soluble in water and in alcohol; insoluble in benzene, in absolute ether, and in solvent hexane.

  • Thioridazine solubility – very soluble in chloroform; freely soluble in dehydrated alcohol and in ether; practically insoluble in water.

  • Tiagabine Hydrochloride solubility – freely soluble in methanol and in alcohol; soluble in isopropanol; very slightly soluble in chloroform; sparingly soluble in water; practically insoluble in n-heptane.

  • Ticagrelor solubility – freely soluble in methanol; soluble in ethanol; practically insoluble in water.

  • Tigecycline solubility – freely soluble in water; soluble in 1-octanol; slightly soluble in methanol, in ethanol, and in isopropyl alcohol.

  • Tilmicosin solubility – slightly soluble in water and in n-hexane.

  • Timolol Maleate solubility – soluble in water, in alcohol, and in methanol; sparingly soluble in chloroform and in propylene glycol; insoluble in ether and in cyclohexane.

  • Titanium Dioxide solubility – insoluble in water, in hydrochloric acid, in nitric acid, and in 2 N sulfuric acid.

  • Tizanidine Hydrochloride solubility – slightly soluble in water and in methanol.

  • Tobramycin solubility – freely soluble in water; very slightly soluble in alcohol; practically insoluble in chloroform and in ether.

  • Tolazamide solubility – freely soluble in chloroform; soluble in acetone; slightly soluble in alcohol; very slightly soluble in water.

  • Tolazoline Hydrochloride solubility – freely soluble in water and in alcohol.

  • Tolbutamide solubility – soluble in alcohol and in chloroform; practically insoluble in water.

  • Tramadol Hydrochloride solubility – freely soluble in water and in methanol; very slightly soluble in acetone.

  • Tranexamic Acid solubility – freely soluble in water and in glacial acetic acid; practically insoluble in acetone and in alcohol.

  • Travoprost solubility – insoluble in water.

  • Trazodone Hydrochloride solubility – sparingly soluble in chloroform and in water.

  • Triazolam solubility – soluble in chloroform; slightly soluble in alcohol; practically insoluble in ether and in water.

  • Tributyl Citrate solubility – freely soluble in alcohol, in isopropyl alcohol, in acetone, and in toluene; insoluble in water.

  • Trichlormethiazide solubility – freely soluble in acetone; soluble in methanol; sparingly soluble in alcohol; very slightly soluble in water, in ether, and in chloroform.

  • Triethyl Citrate solubility – soluble in water. Miscible with alcohol and with ether.
  • Trihexyphenidyl Hydrochloride – soluble in alcohol and in chloroform; slightly soluble in water.

  • Trimethoprim solubility – soluble in benzyl alcohol; sparingly soluble in chloroform and in methanol; slightly soluble in alcohol and in acetone; very slightly soluble in water; practically insoluble in ether and in carbon tetrachloride.

  • Tromethamine solubility – freely soluble in water.

  • Tyloxapol solubility – soluble in glacial acetic acid, in benzene, in toluene, in carbon tetrachloride, in chloroform, and in carbon disulfide.

  • Ursodiol solubility – freely soluble in alcohol and in glacial acetic acid; sparingly soluble in chloroform; slightly soluble in ether; practically insoluble in water.

  • Valproic Acid solubility – freely soluble in 1 N sodium hydroxide, in methanol, in alcohol, in acetone, in chloroform, in benzene, in ether, and in n-heptane; slightly soluble in water and in 0.1 N hydrochloric acid.

  • Valsartan solubility – freely soluble in anhydrous ethanol; sparingly soluble in methylene chloride; practically insoluble in water.

  • Vancomycin Hydrochloride solubility – freely soluble in water; insoluble in ether and in chloroform.

  • Venlafaxine Hydrochloride solubility – soluble in methanol and in water.

  • Verapamil Hydrochloride solubility – freely soluble in chloroform; soluble in water; sparingly soluble in alcohol; practically insoluble in ether.

  • Vinblastine Sulfate solubility – freely soluble in water.

  • Vincristine Sulfate solubility – freely soluble in water; soluble in methanol; slightly soluble in alcohol.

  • Vitamin A solubility – very soluble in chloroform and in ether; soluble in absolute alcohol and in vegetable oils; insoluble in water and in glycerin. In solid form, may be dispersible in water.

  • Vitamin E solubility – insoluble in water; soluble in alcohol; miscible with ether, with acetone, with vegetable oils, and with chloroform.

  • Voriconazole solubility – freely soluble in acetone and in methylene chloride; very slightly soluble in water.

  • Warfarin Sodium solubility – very soluble in water; freely soluble in alcohol; very slightly soluble in chloroform and in ether.

  • Wax (Carnauba) solubility – freely soluble in warm benzene; soluble in warm chloroform and in warm toluene; slightly soluble in boiling alcohol; insoluble in water.

  • Xanthan Gum solubility – soluble in hot or cold water.

  • Zinc Chloride solubility – very soluble in water; freely soluble in alcohol and in glycerin. Its solution in water or in alcohol is usually slightly turbid, but the turbidity disappears when a small quantity of hydrochloric acid is added.

  • Zinc Oxide solubility – soluble in dilute acids; insoluble in water and in alcohol.

  • Zinc Sulfate solubility – very soluble in water (heptahydrate); freely soluble in water (monohydrate) and in glycerin (heptahydrate); practically insoluble in alcohol (monohydrate); insoluble in alcohol (heptahydrate).

  • Zolpidem Tartrate solubility – sparingly soluble in methanol; slightly soluble in water; practically insoluble in methylene chloride.

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