Pharma Digest
Fumigation in Pharmaceutical Industry
Fumigation is an important process in maintaining sterile conditions in pharmaceutical manufacturing areas. Here’s an overview of fumigation in sterile areas within the pharmaceutical industry: Purpose of Fumigation Common Fumigants Fumigation Process Steps Preparation: Sealing the Area: Application: Exposure Time: Ventilation: Safety Considerations Regulatory Compliance Documentation and Validation Read also: ... Read More
Seamless Technology Transfer in Topical Products
Technology transfer (TT) is crucial for ensuring product consistency, compliance, and scalability in topical formulations (creams, gels, ointments). A structured TT minimizes risks in scale-up, process validation, and site transfers. R&D to Manufacturing Transfer Site-to-Site Transfer Successful TT requires QbD-driven process control, cross-functional collaboration, and regulatory alignment to ensure smooth ... Read More
Clean-in-Place in pharmaceutical Industry
CIP, or Clean-in-Place, is a critical process in the pharmaceutical industry, ensuring that equipment and systems are effectively cleaned without disassembly. Importance of CIP in Pharmaceuticals Key Components of CIP Systems Steps in a CIP Process Read also: Resource Person: Omar Salah
Nonviable Particle in Sterile Manufacturing
In sterile environments, non-viable particles are non-living particulate matter like dust, skin cells, or fibers that can act as a carrier for viable particles and pose a risk to product sterility, necessitating monitoring and control. Nature of Non-Viable Particles Non-viable particles include: Sources of Contamination Non-viable particles can enter sterile ... Read More
Common QC Lab Errors in Pharma
Q: What are the major root causes of QC lab errors? Q: What is a common error in HPLC sample preparation? A: Improper sample dissolution leading to inaccurate quantification, peak area variability, and inconsistent retention times. Q: What are the root causes of this issue and How it resolved? A: ... Read More
Sink Factor in Dissolution Testing
Dissolution testing is a cornerstone of pharmaceutical development, providing invaluable insights into how drugs behave in the body. One critical aspect often overlooked is the sink factor and its pivotal role in ensuring the accuracy and relevance of dissolution results. What is Sink Factor? Sink factor refers to the ratio ... Read More
Biodegradable Polymers in Drug Delivery
Exploring the eco-friendly side of pharmaceuticals with biodegradable polymers like Polylactic Acid (PLA). Learn how these sustainable materials are making waves in drug delivery, providing therapeutic benefits while minimizing environmental impact. Advantages of PLA in Drug Delivery Real-time Examples of PLA in Drug Delivery Read also: Resource Person: Pradip Kokane
Biotechnology in Drug Discovery
In the dynamic landscape of pharmaceuticals, biotechnology has emerged as a powerful tool. From genetic engineering to the manipulation of biological systems, biotech methods are instrumental in identifying novel drug targets and designing innovative therapies. Genomic Medicine Unraveling the mysteries encoded in our genes, genomic medicine is revolutionizing how we ... Read More
Nanotechnology in Drug Formulation
Today, let’s embark on a journey into the fascinating realm of nanotechnology in drug formulation. Discover how nanoparticles are reshaping the pharmaceutical landscape, driving innovation, and transforming patient care. The Role of Nanotechnology Precision Delivery Abraxane (Paclitaxel Albumin-bound Nanoparticles)Nanoparticles enable targeted delivery of therapeutics to specific cells or tissues, enhancing ... Read More
Solid Dispersions in Pharmaceutical Formulations
Solid dispersions stand as a cornerstone of modern pharmaceutical formulation, offering innovative solutions to enhance drug solubility, bioavailability, and therapeutic efficacy. Understanding Solid Dispersions: Solid dispersions involve dispersing one or more active pharmaceutical ingredients (APIs) within a solid matrix, typically a polymer or carrier material. This approach addresses challenges associated ... Read More
The Science Behind Effervescent Tablets
Ever marveled at the rapid fizz of an effervescent tablet? Behind that effervescence lies a meticulously crafted blend of excipients, each serving a crucial role in the tablet’s formulation. Acidulants: Think citric acid or tartaric acid. These key players react with bicarbonates, like sodium bicarbonate or potassium bicarbonate, triggering the ... Read More