Pharmaceutical Calculation
TIP Speed Calculation for RMG Process Scale-Up
Scaling up in pharmaceutical manufacturing, especially with Rapid Mixer Granulators (RMG), requires careful attention to “Motion similarity between lab RMG and production Large RMG “, particularly in maintaining consistent “tip speed”. Here’s why this is crucial:Tip speed—the speed at the edge of the rotating impeller directly affects mixing efficiency and ... Read More
Difference Among Assay on As is Basis, on Dried Basis and on Anhydrous Basis
A. Assay on an As is basis refers to the measurement of the content of a substance in its original state, without any removal of water or other volatile components. This type of assay is used when the presence of water or other volatile components does not affect the accuracy ... Read More
Framingham Risk Score Calculation
The Framingham Risk Score (FRS) is a widely used tool for estimating an individual’s 10-year risk of developing cardiovascular disease (CVD). It was developed based on data collected from the Framingham Heart Study, a long-term, ongoing cardiovascular study initiated in 1948 in Framingham, Massachusetts, USA. Risk based upon: Recommended to ... Read More
Basics of Control Chart in Pharmaceutical Industry
Control Charts is a statistical tool to determine if a process is in control. Types of Control Charts Variable Control Charts Deal with items that can be measured. For examples:1) Weight2) Height3) Speed4) Volume Types of Variable Control Charts Attribute Control Charts Control charts that factor in the quality attributes ... Read More
Three Systems of Measurement Used in Pharmacy
Three are three common measurement systems in pharmacy – the metric system, the apothecary system and the avoirdupois system. The metric system includes units of weight, volume, and linear measure; the apothecary system includes units of weight and volume; and the avoirdupois system includes only units of weight. The Metric ... Read More
Cleaning Validation Acceptance Criteria Calculation
The cleaning validation acceptance criteria preferably should be based on the Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) calculations whenever this data is available. The APIC Guidance refers primarily to ADE in the examples of calculations included in this chapter, in line with the ISPE recommended calculations. Acceptance ... Read More
Unit of Measurement in Pharmacy Practices
Metric SystemThis is a decimal system of weights and measures originally based on the meter as the unit of length and the kilogram as the unit of mass. SI SystemThe International system of units was adopted by the 11th General Conference of Weights and Measures in 1960. The SI units ... Read More