Physicochemical properties are all the physical and chemical properties of a drug, which are influence the drug performance or action. Various Physico-Chemical Properties of Drugs Thermodynamic properties Kinetic properties Spectroscopic properties Surface properties Mechanical properties Packing properties If a deficiency is detected, then the project team should decide on the molecular modification(s) that would most…
Drug discovery is part luck and part structured investigation. At the beginning of the 19th century it was largely carried out by individuals but it now requires teamwork, the members of the team being specialists in various fields, such as medicine, biochemistry, chemistry, computerized molecular modeling, pharmaceutics, pharmacology, microbiology, toxicology, physiology and pathology. The approach…
The action of a drug is believed to be due to the interaction of that drug with endogenous and exogenous substrate molecules found in the body. When one or more active drug molecules bind to the target endogenous and exogenous molecules, they cause a change or inhibit the biological activity of these molecules. The effectiveness…
Biological molecules are the basic building blocks of all biological structures and processes that are the basis of life as we know it. A basic knowledge of the nomenclature and structures of these more common endogenous classes of biological molecules is essential to understanding medicinal chemistry. There are four major classes of biological momolecules and…