Pharma Blog
Seamless Technology Transfer in Topical Products
Technology transfer (TT) is crucial for ensuring product consistency, compliance, and scalability in topical formulations (creams, gels, ointments). A structured TT minimizes risks in scale-up, process validation, and site transfers. R&D to Manufacturing Transfer Site-to-Site Transfer Successful TT requires QbD-driven process control, cross-functional collaboration, and regulatory alignment to ensure smooth ... Read More
Clean-in-Place in pharmaceutical Industry
CIP, or Clean-in-Place, is a critical process in the pharmaceutical industry, ensuring that equipment and systems are effectively cleaned without disassembly. Importance of CIP in Pharmaceuticals Key Components of CIP Systems Steps in a CIP Process Read also: Resource Person: Omar Salah
Nonviable Particle in Sterile Manufacturing
In sterile environments, non-viable particles are non-living particulate matter like dust, skin cells, or fibers that can act as a carrier for viable particles and pose a risk to product sterility, necessitating monitoring and control. Nature of Non-Viable Particles Non-viable particles include: Sources of Contamination Non-viable particles can enter sterile ... Read More
Common QC Lab Errors in Pharma
Q: What are the major root causes of QC lab errors? Q: What is a common error in HPLC sample preparation? A: Improper sample dissolution leading to inaccurate quantification, peak area variability, and inconsistent retention times. Q: What are the root causes of this issue and How it resolved? A: ... Read More
Pharmaceutical Disintegrants and It’s Mechanism of Action
Croscarmellose Sodium(CCS) Crospovidone Sodium Starch Glycolate Microcrystalline Cellulose(MCC) Pre-Gelatinized Starch Low-Substituted Hydroxypropyl Cellulose (L-HPC) Ion Exchange Resins (e.g., Polacrilin Potassium) Read also:
Sink Factor in Dissolution Testing
Dissolution testing is a cornerstone of pharmaceutical development, providing invaluable insights into how drugs behave in the body. One critical aspect often overlooked is the sink factor and its pivotal role in ensuring the accuracy and relevance of dissolution results. What is Sink Factor? Sink factor refers to the ratio ... Read More
Key Challenges in Bioequivalence (BE) Studies
Bioequivalence (BE) studies are the foundation of generic drug approvals, ensuring that alternative formulations provide the same therapeutic effect as the reference product. However, regulatory expectations and methodologies are evolving rapidly to address complex formulations and emerging technologies. Key Challenges in BE Studies Complex Generics & Locally Acting Drugs Highly ... Read More
Novel Polymers in Drug Delivery
From the precision of controlled drug release with Hydroxypropyl Methylcellulose (HPMC) to the sophistication of targeted delivery systems using Polyethylene Glycol (PEG), novel polymers are reshaping the landscape of drug development. Let’s dive into the realms of innovation and unlock the possibilities! Advantages of PLGA (Poly(lactic-co-glycolic acid)) Real-time Examples of ... Read More
Biodegradable Polymers in Drug Delivery
Exploring the eco-friendly side of pharmaceuticals with biodegradable polymers like Polylactic Acid (PLA). Learn how these sustainable materials are making waves in drug delivery, providing therapeutic benefits while minimizing environmental impact. Advantages of PLA in Drug Delivery Real-time Examples of PLA in Drug Delivery Read also: Resource Person: Pradip Kokane
Biotechnology in Drug Discovery
In the dynamic landscape of pharmaceuticals, biotechnology has emerged as a powerful tool. From genetic engineering to the manipulation of biological systems, biotech methods are instrumental in identifying novel drug targets and designing innovative therapies. Genomic Medicine Unraveling the mysteries encoded in our genes, genomic medicine is revolutionizing how we ... Read More