Academia
Humoral Control of the Circulation
Humoral control of the circulation means control by substances secreted or absorbed into the body fluids- such as hormones and locally produced factors. Among the most important of the humoral factors that affect circulatory function are the following: Vasoconstrictor Agents Norepinephrine and Epinephrine: Norepinephrine is an especially powerful vasoconstrictor hormone; ... Read More
Physicochemical Properties of Drugs
Physicochemical properties are all the physical and chemical properties of a drug, which are influence the drug performance or action. Various Physico-Chemical Properties of Drugs Thermodynamic properties Kinetic properties Spectroscopic properties Surface properties Mechanical properties Packing properties If a deficiency is detected, then the project team should decide on the ... Read More
Computer Aided Drug Design (CADD)
Computer Aided Drug Design (CADD) has now become an indispensable tool in the long process of drug discovery and development. It includes finding, developing and analyzing medicines and related biological active compounds by computer methodologies. The reliability of the mathematical methods used to obtain and solve the equations is well ... Read More
An Introduction to Lead and Analogue Synthesis
Once the structure of a lead has been decided it is necessary to design a synthetic pathway to produce that lead. These pathways may be broadly classified as either partial or full synthetic routes. The chemical reactions selected for the proposed synthetic pathway will obviously depend on the structure of ... Read More
Structure Activity Relationship in Medicinal Chemistry
Structure-Activity Relationship (SAR) is an approach to find the relationships between a chemical structure of a molecule and its biological activity. SARs are usually determined by making minor changes to the structure of a lead to produce analogues and assessing the effect these structural changes have on biological activity. This ... Read More
Introduction to Drug Discovery
Drug discovery is part luck and part structured investigation. At the beginning of the 19th century it was largely carried out by individuals but it now requires teamwork, the members of the team being specialists in various fields, such as medicine, biochemistry, chemistry, computerized molecular modeling, pharmaceutics, pharmacology, microbiology, toxicology, ... Read More
Introduction to Drug Action
The action of a drug is believed to be due to the interaction of that drug with endogenous and exogenous substrate molecules found in the body. When one or more active drug molecules bind to the target endogenous and exogenous molecules, they cause a change or inhibit the biological activity ... Read More
Biological Molecules Notes for Bachelor Students
Biological molecules are the basic building blocks of all biological structures and processes that are the basis of life as we know it. A basic knowledge of the nomenclature and structures of these more common endogenous classes of biological molecules is essential to understanding medicinal chemistry. There are four major ... Read More
Department of Hospital Pharmacy
The department or service in a hospital which is under the direction of a professionally competent, legally qualified pharmacists, and from which all medications are supplied to the nursing units and other services, special prescriptions are filled for patients in the hospital, for ambulatory patients and out-patients, pharmaceuticals are manufactured ... Read More
Major Job Responsibilities of a Clinical Pharmacist
Clinical pharmacy is a health science discipline in which pharmacists provide the patient care that optimizes medication therapy and promotes health, wellness, and disease prevention. Where do clinical pharmacists work? A clinical pharmacists work directly with doctors, other health care professionals, and patients to ensure that the medications prescribed for ... Read More