Clinical Pharmacy
Novel Polymers in Drug Delivery
From the precision of controlled drug release with Hydroxypropyl Methylcellulose (HPMC) to the sophistication of targeted delivery systems using Polyethylene Glycol (PEG), novel polymers are reshaping the landscape of drug development. Let’s dive into the realms of innovation and unlock the possibilities! Advantages of PLGA (Poly(lactic-co-glycolic acid)) Real-time Examples of ... Read More
Biodegradable Polymers in Drug Delivery
Exploring the eco-friendly side of pharmaceuticals with biodegradable polymers like Polylactic Acid (PLA). Learn how these sustainable materials are making waves in drug delivery, providing therapeutic benefits while minimizing environmental impact. Advantages of PLA in Drug Delivery Real-time Examples of PLA in Drug Delivery Read also: Resource Person: Pradip Kokane
Nanotechnology in Drug Formulation
Today, let’s embark on a journey into the fascinating realm of nanotechnology in drug formulation. Discover how nanoparticles are reshaping the pharmaceutical landscape, driving innovation, and transforming patient care. The Role of Nanotechnology Precision Delivery Abraxane (Paclitaxel Albumin-bound Nanoparticles)Nanoparticles enable targeted delivery of therapeutics to specific cells or tissues, enhancing ... Read More
General Adverse Events in Clinical Trials
FATIGUE: Persistent tiredness not relieved by rest. FEVER: Elevated body temperature due to infection or inflammation. HEADACHE: Pain or discomfort in the head or upper neck. DIZZINESS: A feeling of lightheadedness or unsteadiness. NAUSEA: Sensation of wanting to vomit. VOMITING: Forceful expulsion of stomach contents. DIARRHEA: Frequent, watery bowel movements. ... Read More
Pharmacokinetics of Naproxen
In linear pharmacokinetics (PK), when we increase the dose (D) of the drug, its level in our body or systemic exposure (AUC) increases proportionally (red curve on left graph). What is our inference? This implies that both oral bioavailability (F) and clearance (CL) are constant such that dose (D) and ... Read More
Classification of Antibiotics
Inhibitors of Cell Wall Synthesis These antibiotics target the bacterial cell wall, leading to lysis and death. Beta-lactams: Interfere with peptidoglycan synthesis by inhibiting penicillin-binding proteins (PBPs).Examples: Glycopeptides: Bind to peptidoglycan precursors, preventing cross-linking.Examples: Vancomycin, Teicoplanin. Others: Bacitracin (used topically). Inhibitors of Protein Synthesis These antibiotics target bacterial ribosomes, disrupting ... Read More
ESC Key Notes on Obesity and Cardiovascular Disease
European Society of Cardiology (ESC) Clinical Consensus Statement on Obesity and Cardiovascular Disease Read also: Read also: Dr. Suzan Gharaibeh
Prevention or Delay of Diabetes | Standards of Care in Diabetes 2024
In people with prediabetes, monitor for the development of type 2 diabetes at least annually; modify based on individual risk assessment. Refer adults with overweight or obesity at high risk of DM2, as seen in the Diabetes Prevention Program (DPP), to an intensive lifestyle behavior change program to achieve and ... Read More
Citrus Food with Substrate of Pgp and CYP3A4
Do we know that jabara is a Japanese citrus that is similar to yuzu and is consumed as an anti-allergic functional food in Japan and worldwide? We have previously discussed how grapefruit juice interacts with medications (drugs). A question arises: does jabara also interact with drugs? Guess what? It has ... Read More
Concepts of Elimination Rate and Clearance of Drugs
Have we come across a presenter who commented that the ‘clearance rate of a drug is high or low’? A question arises: Is clearance an elimination rate of a given drug? Some of us remain unclear regarding the concepts of elimination rate and clearance of drugs. Elimination rate is the ... Read More