Croscarmellose Sodium(CCS)
- Role: Improves tablet hardness while ensuring rapid disintegration.
- How It Works: Forms a microscopic network during compression to reinforce tablet structure.
- Benefit: Fewer cracked tablets during high-speed production, especially for sensitive API .
Crospovidone
- Role: Acts as a disintegrant while maintaining tablet stability.
- How It Works: Absorbs ambient moisture to protect hygroscopic drugs, such as amoxicillin, from clumping.
- Benefit: Enhanced drug stability and reduced need for specialized humidity-controlled packaging.
Sodium Starch Glycolate
- Role: Enhances the dissolution of tablets.
- How It Works: Creates a localized alkaline environment that speeds up the breakdown of acidic drugs like ibuprofen.
- Benefit: Optimized release profiles and improved integration in enteric coatings.
Microcrystalline Cellulose(MCC)
- Role: Improves solubility and powder flow during direct compression.
- How It Works: Enhances the dissolution of poorly soluble drugs (e.g., griseofulvin)and smooths manufacturing processes.
- Benefit: More consistent production with fewer processing interruptions.
Pre-Gelatinized Starch
- Role: Serves as both a binder and a disintegrant.
- How It Works: Reduces the need for extra binders in formulations such as paracetamol granules.
- Benefit: Streamlined formulation and shorter R&D timelines.
Low-Substituted Hydroxypropyl Cellulose (L-HPC)
- Role: Functions as a disintegrant and binder.
- Porosity Enhancement: Its fibrous structure increases tablet porosity for faster dissolution.
- Granulation Aid: Improves cohesiveness of granules in wet granulation.
- Benefit: Facilitates rapid tablet breakdown and contributes to efficient granulation.
Ion Exchange Resins (e.g., Polacrilin Potassium)
- Role: Swell in ionic solutions.
- Taste Masking: Binds bitter drugs through ionic interactions to improve palatability.
- Controlled Release: Modulates drug release through ion-exchange mechanisms.
- Benefit: Enhanced patient compliance with improved taste and controlled release profiles.
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