Biorelevant Media

At Level III of biorelevant media simulation, a comprehensive replication of the gastrointestinal (GI) tract environment includes factors such as luminal osmolality, pH range, buffer capacity using specific buffer ingredients, bile components, dietary lipid components, dietary proteins, increased viscosity (notably in the fed stomach and lower intestine), and the replication ... Read More

Developing accurate models of the gastrointestinal (GI) tract is paramount in pharmaceutical research to predict how drugs interact with the human body. Level II biorelevant media emerges as a sophisticated tool to mirror the intricate conditions within the GI system, playing a pivotal role in enhancing drug formulation and assessment. ... Read More

When studying drug dissolution in the gastrointestinal (GI) tract, simulating realistic physiological conditions is crucial for accurate results. Enter Level I biorelevant media – a novel approach to create in vitro environments that closely mimic luminal pH and buffer capacity in different regions of the GI tract. At Level I, ... Read More

Biorelevant media were initially proposed in 1998 to study the dissolution of poorly soluble drugs in the gastrointestinal (GI) tract. Over time, different media have been developed to mimic various parts of the GI tract in both fasted and fed states. For the fasted state, there are specific biorelevant media ... Read More