F2 Value
Is f₂ in Multimedia a True Indicator of Bioequivalence?
The f₂ similarity factor is a commonly used mathematical tool in pharmaceutical development to compare the dissolution profiles of a test product and its reference listed drug (RLD). When the calculated f₂ value is ≥ 50, it indicates that the two profiles are similar under the tested conditions. Regulatory agencies ... Read More
Does an F2 Similarity Value of 50 Mean the Two Dissolution Profiles are Only 50% Similar?
No, the similarity factor (F2) is a mathematical representation of the quadratic mean difference between two dissolution profiles across all considered time points. An F2 value of 50 indicates that the two profiles differ by a small margin, with a mean difference of approximately 10%. The similarity factor is not ... Read More