Pharma Digests
Asthma Management Guidelines
Asthma is one of the most common chronic disease. In which the reversible airways obstruction and bronchospasm occur and may produce extra mucus. This can make breathing problem and trigger coughing. This is a globally significant non-communicable disease with major public health consequences for both children and adults, including high ... Read More
Three Systems of Measurement Used in Pharmacy
There are three common measurement systems in pharmacy – the metric system, the apothecary system and the avoirdupois system. The metric system includes units of weight, volume, and linear measure; the apothecary system includes units of weight and volume; and the avoirdupois system includes only units of weight. The Metric ... Read More
Unit of Measurement in Pharmacy Practices
Metric SystemThis is a decimal system of weights and measures originally based on the meter as the unit of length and the kilogram as the unit of mass. SI SystemThe International system of units was adopted by the 11th General Conference of Weights and Measures in 1960. The SI units ... Read More
Computer Aided Drug Design (CADD)
Computer Aided Drug Design (CADD) has now become an indispensable tool in the long process of drug discovery and development. It includes finding, developing and analyzing medicines and related biological active compounds by computer methodologies. The reliability of the mathematical methods used to obtain and solve the equations is well ... Read More
An Introduction to Lead and Analogue Synthesis
Once the structure of a lead has been decided it is necessary to design a synthetic pathway to produce that lead. These pathways may be broadly classified as either partial or full synthetic routes. The chemical reactions selected for the proposed synthetic pathway will obviously depend on the structure of ... Read More
Structure Activity Relationship in Medicinal Chemistry
Structure-Activity Relationship (SAR) is an approach to find the relationships between a chemical structure of a molecule and its biological activity. SARs are usually determined by making minor changes to the structure of a lead to produce analogues and assessing the effect these structural changes have on biological activity. This ... Read More
Introduction to Drug Discovery
Drug discovery is part luck and part structured investigation. At the beginning of the 19th century it was largely carried out by individuals but it now requires teamwork, the members of the team being specialists in various fields, such as medicine, biochemistry, chemistry, computerized molecular modeling, pharmaceutics, pharmacology, microbiology, toxicology, ... Read More
Introduction to Drug Action
The action of a drug is believed to be due to the interaction of that drug with endogenous and exogenous substrate molecules found in the body. When one or more active drug molecules bind to the target endogenous and exogenous molecules, they cause a change or inhibit the biological activity ... Read More
Factors Affecting Solubility of Drugs
Solubility is defined as the upper limit of solute that can be dissolved in a given amount of solvent at equilibrium. It is also called the ability of substance to dissolve in a solvent.orThe solubility is defined as the concentration of the solute in solution when it is in equilibrium ... Read More
Biological Molecules Notes for Bachelor Students
Biological molecules are the basic building blocks of all biological structures and processes that are the basis of life as we know it. A basic knowledge of the nomenclature and structures of these more common endogenous classes of biological molecules is essential to understanding medicinal chemistry. There are four major ... Read More
Pharmacokinetic Service in Hospitals
Clinical pharmacokinetics is the tools that can be used to optimize pharmaceutical care services by determining the dosage regimens of specific drug products for specific patients to maximize pharmacotherapeutic effects and minimize toxic effects. A list of pharmacokinetic services are mentioned below: (1) Designing patient-specific Medication dosage regimens based on ... Read More