Clinical Pharmacy
Pulmonary Embolism | A Life-Threatening Condition
As a professional pharmacist, it’s critical to shed light on Pulmonary Embolism (PE), a serious condition that can be life-threatening if not promptly treated. What is Pulmonary Embolism? PE occurs when a blood clot travels to the lungs, blocking one or more pulmonary arteries. This blockage can severely impair lung ... Read More
FDA Clinical Study Requirements for IND
Clinical study requirements for an Investigational New Drug (IND) application are designed to ensure the safety and efficacy of the investigational drug during human trials. Here are the key aspects and requirements: Clinical Study Protocol A detailed clinical study protocol must be included in the IND application. This protocol should ... Read More
Diabetes and Foot Care Recommendations
American Diabetes Association (ADA) Standards of Care 2024: 1. Perform a comprehensive foot evaluation at least annually to identify risk factors for ulcers and amputations. 2. The examination should include inspection of the skin, assessment of foot deformities, neurological assessment (10-g monofilament testing with at least one other assessment: pinprick, ... Read More
Insulin Therapy in Type 2 Diabetes
ADA Standards of Care 2024 1. Many adults with type 2 diabetes eventually require and benefit from insulin therapy. The progressive nature of type 2 diabetes should be regularly and objectively explained to individuals with diabetes, and clinicians should avoid using insulin as a threat or describing it as a ... Read More
LYRICA (Pregabalin) | Drug Digest
LYRICA (pregabalin) has been Pfizer’s flagship blockbuster brand for many years due to the fact that it has been approved in multiple indications. It has also been the highest-selling neurology brand for several years. As such, the company has tried using aggressive strategies to extend the brand’s lifecycle in order ... Read More
ACCUTANE (Isotretinoin) | Drug Digest
ACCUTANE (isotretinoin) is indicated for the treatment of: Because of significant side effects associated with its use, ACCUTANE should be reserved for patients where the conditions listed above are unresponsive to conventional first line therapies. ACCUTANE should only be prescribed by physicians knowledgeable in the use of retinoids systemically, who ... Read More
Effective Design of Clinical Trials | FDA
The 1962 FD&C Act Prior to 1962, drug safety was the primary concern, but the act revolutionized the landscape by demanding substantial evidence of a drug’s effectiveness. This shift led to the requirement of “adequate and well-controlled studies” – a cornerstone of modern clinical research. 𝗔𝗱𝗲𝗾𝘂𝗮𝘁𝗲 𝗮𝗻𝗱 𝗪𝗲𝗹𝗹-𝗖𝗼𝗻𝘁𝗿𝗼𝗹𝗹𝗲𝗱 𝗦𝘁𝘂𝗱𝗶𝗲𝘀: 𝗧𝗵𝗲 ... Read More
Metformin Tablets | Drug Digest
Current treatment guidelines recommend initiating metformin as first line pharmacotherapy unless a contraindication or intolerability exists. Metformin consistently reduces A1C levels by 1.5% to 2.0% and FPG levels by 60 to 80 mg/dL (3.3 to 4.4 mmol/L) in drug naive patients with A1C values of approximately 9%. Metformin does not ... Read More
Marochym-200 (Trypsin & Chymotrypsin) Tablets
Composition: trypsin and chymotrypsin are oral proteolytic enzymes that hasten the repair of traumatic, surgical and orthopedic procedures. The combination of these two enzymes in this product grants it anti-inflammatory, anti-edematous, fibrinolytic, antioxidant and anti-infective properties. Mechanism of action: Trypsin and chymotrypsin resolve swelling by exerting proteolytic action on wounds. ... Read More
DAYVIGO (Lemborexant) for Insomnia
DAYVIGO (lemborexant) is indicated for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance. Lemborexant is a competitive antagonist of both orexin receptors, OX1R and OX2R, with a higher affinity for OX2R. It belongs to the pharmacologic class of orexin receptor antagonists. The orexin neuropeptide signaling ... Read More
SEROQUEL (Quetiapine Fumarate) | Antipsychotic Agent
Indications: Notes: Serious Warnings and Precautions: Monitoring and Tests: Others: Precautions: SEROQUEL can cause serious side effects including: Note: SEROQUEL is not a cure, but it can help manage symptoms. The following may interact with SEROQUEL: Usual dose: SchizophreniaStarting dose is 25 mg, twice daily. The recommended dose range is ... Read More