Tablet
How do We Ensure that Split Tablets Maintain Dose Accuracy and Stability?
For those who need flexible dosing, tablet splitting (for tablets with a functional score-line) can be helpful, but it’s essential to ensure each piece is consistent and effective. Here’s a quick look at the *key tests and acceptance criteria to assess splitting of scored immediate-release tablets. To ensure quality and ... Read More
Basics of Tablet Tooling
Tooling can be defined as tools to craft a particular shape. Tableting tools i.e., Punches and dies are essential tools to shape any granules into a solid dosage form by applying compaction force in a compression machine. Any shape be it round, oblong or bullet shape or any special shape ... Read More
Coating Process in Pharmaceutical Industry
Although both sugar coating and film coating are utilized by a significant number of pharmaceutical companies worldwide, the film-coating process is the one most often preferred today. Film coating was formally introduced into the pharmaceutical industry in the middle of the last century. It should be noted that there has ... Read More
Compression Process in Tablet Manufacturing
Compression or compaction is the pharmaceutical unit operation of applying pressure or force to the powder to densify it and generate the physical bonds between the powder particles. The critical parameters of this operation are (1) the material properties of the particles being compacted and (2) the equipment used for ... Read More
Blending Process in Pharmaceutical industry
Blending or Mixing are the reorientation of particles relative to one another in order to achieve uniformity. Types of Blending Operating Principles of Blending Diffusion Blending (Tumble) Particles are reoriented in relation to one another when they are placed in random motion and inter particular friction is reduced as the ... Read More
Milling Process in Pharmaceutical Industry
Milling is a mechanical process of breaking particles into smaller pieces via one or more particle size reduction mechanisms. Types of Milling Milling Operation Principles Milling Equipment Classifications 1. Fluid Energy Mills Fluid energy mill subclasses have no moving parts and primarily are distinguished from one another by the configuration ... Read More
Granulation Process in Pharmaceutical Tablet Manufacturing
Granulation is the process of creating granules. The powder morphology is modified through the use of either a liquid that causes particles to bind through capillary forces or dry compaction forces. Importance of Granulation in Pharmaceutical Industry The granulation process will result in one or more of the following powder ... Read More
Pharmaceutical Tablet Preparation Process
Most compacted (compressed) tablets consist of the drug substance(s) and a number of excipients. These excipients may include fillers (diluents), binders, disintegrating agents, lubricants, and glidants. Approved FD&C and D&C dyes or lakes, flavors, and sweetening agents also may be present. Tablets are prepared from formulations that have been processed ... Read More
Pharmaceutical Oral Solid Dosage Form
Oral delivery is the most common route of administration for drug products. Pharmaceutical solid oral drug products include but are not limited to capsules, tablets, granules, and powders. Capsules Capsules are solid dosage forms in which the drug substance and/or excipients are enclosed within a soluble container or shell or ... Read More
Types of Pharmaceutical Dosage Form
A dosage form is a pharmaceutical preparation consisting of drug substance(s) and/or excipient(s) to facilitate dosing, administration, and delivery of the content of the drug product to the patient. It can also define as the manner in which drug substance are commercialized (e.g., solids, liquids or semi solids). As per ... Read More