Ever marveled at the rapid fizz of an effervescent tablet? Behind that effervescence lies a meticulously crafted blend of excipients, each serving a crucial role in the tablet’s formulation.
Acidulants: Think citric acid or tartaric acid. These key players react with bicarbonates, like sodium bicarbonate or potassium bicarbonate, triggering the release of carbon dioxide gas upon contact with water. That’s where the fizz comes from!
Carbonates/Bicarbonates: As mentioned, sodium bicarbonate or potassium bicarbonate provide the carbon dioxide source. It’s the reaction between these carbonates and acidulants that creates those delightful bubbles.
Binders: Polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) ensure the tablet holds its shape and integrity, crucial for consistent dosing.
Fillers: Lactose, mannitol, or sorbitol bulk up the tablet, ensuring uniformity in dosage and aiding in compression during manufacturing.
Flavoring Agents: Who says medicine can’t taste good? Fruit flavors, mint, or other flavoring agents mask any unpleasant taste, making the tablet more palatable.
Sweeteners: Sucrose or sorbitol sweeten the deal, enhancing the tablet’s taste and overall appeal.
Colorants: A touch of aesthetics! Colorants give the tablet its distinctive look, making it instantly recognizable.
Disintegrants: Crospovidone or sodium starch glycolate ensure the tablet breaks apart rapidly upon contact with water, facilitating quick dissolution and absorption.
Ever heard of Effer-Soda? It’s a classic example of effervescent magic! Just drop a tablet into water, and watch it transform into a refreshing beverage before your eyes. From the chemistry of fizz to the art of taste, effervescent tablets embody a harmonious blend of science and innovation.
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Resource Person: Pradip Kokane